PCA PRODUCT LIST (BILIARY DERIVATIVES)
Ursodeoxycholic Acid is a hydrophilic bile acid that occurs naturally in bile. It’s obtained by synthesis starting from Cholic acid. Used to reduce level of cholesterol in the bile and for dissolution of cholesterol, radio-lucent gallstones. Furthermore it shows therapeutic effect in cholestatic liver diseases, improvement in serum liver enzymes and in primary biliary cirrhosis.
In addition it’s efficacious in improving hepatic function, sclerosing cholangitis, cystic fibrosis and chronic hepatitis. Recently it has been demo str ted that UDCA is an antioxidant that suppresses xidative stress in liver and in enterochytis cells.
Tauroursodeoxycholic Ac d is obtained conjugating Ursodeoxycholic Acid nd Taurine. It’s used for dissolving cholesterol radio luce t gallstones, for treating chronic liver diseases with cholestasis, for treating primary biliary cirrhosis and viral and alcoholic chronic hepatitis.
It inhibi s mitochondrial associated apoptosis. In animal models reduce ER stress and restore glucose homeostasis. It’s the main component of human bile and it’s obtained by synthesis starting from Cholic Acid. Mainly used as biological enhancer, solubility agent and drug carrier.
It’s listed as a GRAS (Generally Recognized As Safe) substance by FDA.
Chenodeoxycholic Acid is a natural substance found in human bile. It’s used in the treatment of gall stones disease and it’s obtained by synthesis starting from Cholic Acid. It’s used as intermediate for Ursodeoxycholic acid manufacturing while its pharma grade is used in the treatment of CTX (Cerebrotendinous Xanthomatosis) an extremely rare genetic disease affecting some hundreds people worldwide
Cholic Acid has been detected in the bile of most vertebrates in conjugation with Glycine and Taurine. It’s one of the end product of cholesterol metabolism.
We supply Cholic Acid “Pharmaceutical Grade”.
CHENODEOXYCHOLIC ACID SODIUM SALT
It has been the same pharmacological properties of Chenodeoxycholic acid.
It reduces cholesterol amount, probably by inhibiting liver synthesis, allowing gallstones dissolution.
It’s obtained from Cholic Acid. It has been used to prevent gallstones generation and generally as drug carrier. It has been used in the preparation and formulation of microbiological media. As non ionic detergent is also used to extract membrane proteins.
It’s obtained from Deoxycholic Acid. It’s used as an anionic detergent in the extraction of the membrane receptors and to isolate proteic ions. It’s also used in the preparation of microbiological media.
Recently studies refer about its using in local fat reduction associated with phosphatidylcholine.
TAURODEOXYCHOLIC ACID SODIUM SALT
It’s the sodium salt form of the conjugation between Taurine and Deoxyholic Acid. It’s a biological and very efficacious detergent.
It’s used as a vehicle to support drug or vaccines delivery.
TAUROURSODEOXYCHOLIC ACID SODIUM SALT
It has detergent property.Literature reports its action in inhibiting human cholangiocarcinoma growth.
TAUROCHOLIC ACID SODIUM SALT
It’s the sodium salt form of the conjugation between Taurine
TAUROCHOLIC ACID and Cholic Acid and it’s naturally found in almost all mammal SODIUM SALT animals.It’s used as a biological enhancer, solubiliza ion agent and drug carrier.
GLICOCHOLIC ACID SODIUM SALT
It’s used as a detergent nd in the preparation of microbiological media.
It’s used as a water soluble f rm of Glycocholic Acid.
Deoxycholic Acid is a natural substance found in the intestine as secondary biliary acid obtained by an enzymatic process from Cholic acid.It’s mainly used in the preparation of steroids.
It’s extracted from bovine bile where is found conjugated with Taurine and Glycine.
Its acts as a detergent to dissolve fats improving their absorption in intestine and it’s used as a choleretic detergent. In some countries it was formerly licensed and used as a food additives. It’s listed as a GRAS (Generally Recognized As Safe) substance by FDA.
Dehydrocholic acid is a bile acid obtained by oxidation of hydroxyl groups in position 3, 7 and 12. and it’s used to increase the volume and the water content of the bile to improve biliary drainage.
GLYCODEOXYCHOLIC ACID SODIUM SALT
It’s commonly used s detergent
It’s the product of the conjugation between Ursodeoxycholic Acid and Glycine. It ‘s a secondary bile acids obtained by enzymatic process by intestine microbial flora. Recently clinical study has been run using Glycoursodeoxycholic Acid and interleukin-10 to modulate inflammatory state due to the accumulation of unconjugated bilirubin within brain and resulting in bilirubine encephalopathy
Lithocholic Acid it’s a bile acid that acts as a detergent to dissolve fats and improve their absorption.
It’s under study as a biomarker of intra-hepatic cholestasis of pregnancy during Ursodeoxycholic Acid treatment.
Taurine is a natural amino acid widely found free and conjugated in animals tissue but practically absent in vegetal world. It’s extracted from mother liquor of bovine bile hydrolysis and it’s used as additive in milk for babies, health drinks and for cardiovascular and metabolic disorders.
PCA Product List (THEOPHYLLINE DERIVATIVES)
It’s a theophylline derivative having vasodilator and bronchodilator activities.
Respiratory smooth muscle relaxant actions are well known.
It’s a theophylline derivative having similar pharmacological effect but with more specific bronchodilator activity.
It’s used as carrier in improving ambroxol blood levels. Its salts as acephylline are used as anti-asthmatic.
Xantinol nicotinate contains the pharmacologically active component nicotinic acid combined with the basic theophylline derivative Xantinol. Positive treatment results have been reported in the treatment of cerebral insufficiency and improving short and long term memory; it has trombolytic and hypotensive activity. It has been historically used as vasodilator and to prevent circulatory disease.